Adaptive significance of play: Are we getting closer?

Adaptive significance of play: Are we getting closer?

Life history theory predicts that animals whose activities impose time, energy or survivorship costs at one stage of their lives will subsequently suffer incremental decreases in fitness unless there are compensatory benefits. Play, a widespread activity among juvenile mammals and several orders of birds' appears costly, yet its adaptive significance is poorly understood despite over 15 years o...

Ribozymes as therapeutic agents: are we getting closer?

The biology of ribozymes has come far since the initial seminal observations of self-cleaving molecules in Tetrahymena (1) and ribonuclease P (2). With the discovery of the hammerhead ribozyme (3) came the realization that it could be utilized to potentially disrupt the expression of any target gene in trans (i.e., acting from outside the target gene sequence) (4). As different types of catalyt...

Why are we not getting any closer to preventing suicide?

Defining remission in psoriatic arthritis: are we getting closer?

Noninvasive assessment of cardiac electrophysiology for predicting arrhythmogenic risk: are we getting closer?

Identification of patients at significant risk of arrhythmia and sudden cardiac death is one of today’s major cardiology challenges. Although tremendous progress has been made in detecting and characterizing cardiac disease and its progression, largely through imaging modalities, progress in detecting and monitoring changes in arrhythmogenic states has been incremental and has not resulted in r...